依达拉奉联合丹红注射液对急性脑梗死患者神经功能及血清炎症因子的影响
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摘要
目的探讨依达拉奉联合丹红注射液对急性脑梗死患者神经功能及血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)浓度的影响。方法选取2016年5月至2018年7月廉江市人民医院收治的急性脑梗死患者80例为研究对象,按随机数字表法分为对照组与观察组,每组40例。对照组患者采取常规治疗+胞二磷胆碱注射液+低分子右旋糖酐注射液治疗,观察组患者在对照组常规治疗的基础上采取依达拉奉联合丹红注射液治疗,比较两组患者的临床疗效。结果观察组患者的总有效率为90.0%,显著高于对照组的75.0%,差异有统计学意义(P<0.05);治疗后,观察组患者的日常生活能力评分显著高于对照组,差异有统计学意义(P<0.05),NIHSS评分低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者的血清炎症因子水平均显著下降,且显著低于对照组,差异均有统计学意义(均P<0.05)。结论依达拉奉联合丹红注射液治疗急性脑梗死能改善患者机体的炎症反应,减轻神经功能缺损程度,安全性较好,效果显著,具有临床推广价值。
Objective To explore the effects of Edaravone injection combined with Danhong Injection(丹红注射液) in the neurological function and serum hs-CRP(high-sensitivity C-reactive protein), TNF-α(tumor necrosis factor-α) and IL-6(interleukin-6) concentrations in acute cerebral infarction(ACI) patients. Methods A total of 80 ACI patients treated in Lianjiang People's Hospital from May 2016 to July 2018 were selected as research objects and randomly devided into the control group and the observation group according to random number table, with 40 cases each group. The control group was treated with conventional therapy, citicoline injection and low molecular weight dextran injection, and the observation group was treated with conventional therapy, Edaravone injection with Danhong Injection. The clinical efficacy between the 2 groups was counted. Results The total effective rate of the observation group was 90.0%, which was significantly higher than 75.0% of the control group, and there was statically significant differece(P<0.05). After treatment, the ADL(activity of daily living) scores in the observation group were significantly higher than control group, and there was statical significance(P<0.05). The NIHSS(National Institute of Health stroke scale) scores in the observation group were significantly lower than control group, and there was statical significance(P<0.05). The serum inflammatory factor contents in the observation group were significantly lower than control group, and there was statical significance(P<0.05). Conclusion The Edaravone injection with Danhong Injection can relieve the inflammatory response and neurologic impairments, increase the clinical safety and efficacy, which is worthy for clinical promotion.
Objective To explore the effects of Edaravone injection combined with Danhong Injection(丹红注射液) in the neurological function and serum hs-CRP(high-sensitivity C-reactive protein), TNF-α(tumor necrosis factor-α) and IL-6(interleukin-6) concentrations in acute cerebral infarction(ACI) patients. Methods A total of 80 ACI patients treated in Lianjiang People's Hospital from May 2016 to July 2018 were selected as research objects and randomly devided into the control group and the observation group according to random number table, with 40 cases each group. The control group was treated with conventional therapy, citicoline injection and low molecular weight dextran injection, and the observation group was treated with conventional therapy, Edaravone injection with Danhong Injection. The clinical efficacy between the 2 groups was counted. Results The total effective rate of the observation group was 90.0%, which was significantly higher than 75.0% of the control group, and there was statically significant differece(P<0.05). After treatment, the ADL(activity of daily living) scores in the observation group were significantly higher than control group, and there was statical significance(P<0.05). The NIHSS(National Institute of Health stroke scale) scores in the observation group were significantly lower than control group, and there was statical significance(P<0.05). The serum inflammatory factor contents in the observation group were significantly lower than control group, and there was statical significance(P<0.05). Conclusion The Edaravone injection with Danhong Injection can relieve the inflammatory response and neurologic impairments, increase the clinical safety and efficacy, which is worthy for clinical promotion.
引文
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[2]陈灏珠.实用内科学[M].13版.北京:人民卫生出版社,2009.
[3]王云霄,袁俊亮,胡文立,等.常用卒中量表的研究进展[J].中国卒中杂志,2016,11(12):1072-1077.
[4]李苗苗,代永静.Barthel指数评分量表在康复护理中的应用进展[J].护士进修杂志,2018,33(6):508-510.
[5]叶任高,陆再英.内科学[M].5版.北京:人民卫生出版社,2002.
[6]苏延玲,王红丽,张中华,等.灯盏花素注射液对急性脑梗死患者血液生化指标和血液流变学的影响[J].中国药房,2016,27(27):3802-3804.
[7]杨文月,崔琳,渠玲玲,等.丹参酚酸A和丹参酚酸B与胰岛素相互作用的分子光谱学研究以及葡萄糖的影响[J].光谱学与光谱分析,2016,36(9):3053-3061.
[8]许静,田青.依达拉奉联合丹红注射液治疗急性脑梗死43例疗效观察[J].海南医学,2015,26(21):3199-3201.
[9]杨迎伟,张爱民,李亚梅,等.丹红注射液联合依达拉奉治疗急性脑梗死的临床疗效[J].实用心脑肺血管病杂志,2017,25(11):83-85.
[10]赵卫东.依达拉奉联合丹红注射液治疗急性脑梗死的临床效果[J].河北医药,2017,39(12):1863-1865,1868.
[2]陈灏珠.实用内科学[M].13版.北京:人民卫生出版社,2009.
[3]王云霄,袁俊亮,胡文立,等.常用卒中量表的研究进展[J].中国卒中杂志,2016,11(12):1072-1077.
[4]李苗苗,代永静.Barthel指数评分量表在康复护理中的应用进展[J].护士进修杂志,2018,33(6):508-510.
[5]叶任高,陆再英.内科学[M].5版.北京:人民卫生出版社,2002.
[6]苏延玲,王红丽,张中华,等.灯盏花素注射液对急性脑梗死患者血液生化指标和血液流变学的影响[J].中国药房,2016,27(27):3802-3804.
[7]杨文月,崔琳,渠玲玲,等.丹参酚酸A和丹参酚酸B与胰岛素相互作用的分子光谱学研究以及葡萄糖的影响[J].光谱学与光谱分析,2016,36(9):3053-3061.
[8]许静,田青.依达拉奉联合丹红注射液治疗急性脑梗死43例疗效观察[J].海南医学,2015,26(21):3199-3201.
[9]杨迎伟,张爱民,李亚梅,等.丹红注射液联合依达拉奉治疗急性脑梗死的临床疗效[J].实用心脑肺血管病杂志,2017,25(11):83-85.
[10]赵卫东.依达拉奉联合丹红注射液治疗急性脑梗死的临床效果[J].河北医药,2017,39(12):1863-1865,1868.