严重急性呼吸综合征患者十年生存质量分析
|
摘要
目的对严重急性呼吸综合征(SARS)患者10年后的生存质量进行分析。方法收集确诊为SARS的患者25例为SARS组,健康体检者25例为对照组,2组一般资料差异无统计学意义。采用健康调查简表(SF-36)从生理机能、生理职能、躯体疼痛、一般健康状况、精力、社会功能、情感职能以及精神健康等8个方面对被调查者的生存质量进行评价。比较2组肺功能指标,包括用力肺活量(FVC)、一秒用力呼气容积(FEV1)、一秒率(FEV1/FVC)、肺总量(TLC)、残气容积(RV)、校正后一口气弥散量(TLCOc SB)及校正后弥散率(TLCOc/VA);并分析SARS组各肺功能指标与生存质量各维度评分的相关性。骨MRI扫描检查SARS组患者髋关节与股骨头坏死情况。结果 SARS组中有23例(92.0%)生存质量总评分差,2例(8.0%)生存质量总评分中等。SARS组较对照组各维度生存质量评分偏低(P<0.01)。SARS组仅TLCOc SB低于对照组,生理机能评分与FEV1、FEV1/FVC呈正相关,躯体疼痛评分与FEV1/FVC呈正相关(P<0.05),其他生存质量评分与肺功能指标间均无相关性。SARS组中股骨头非坏死者14例(56%)、坏死者11例(44%)。坏死组各维度生存质量仅生理机能得分低于非坏死组(P<0.05)。结论 SARS患者的生存质量低下既有心理因素也有身体因素,SARS患者的肺通气功能和股骨头坏死影响了患者的生存质量,特别是生理机能。
Objective To analyse the quality of life in patients with severe acute respiratory syndrome(SARS) for 10 years.Methods Twenty-five SARS patients were collected as SARS group and 25 healthy persons were used as control group.There were no significant differences in general clinical data between two groups.The quality of life of the respondents was evaluated by the MOS item short form health survey(SF- 36) including physiological function,physical pain,general health condition,energy,social function,emotional function and mental health.The pulmonary function indicators including forced vital capacity(FVC),one second forced expiratory volume(FEV1),one second rate(FEVl/FVC),total lung capacity(TLC),residual volume(RV),corrected breath diffusing capacity(TLCOc SB) and corrected dispersion rate TLCOc/VA were also compared between two groups.The correlation between each dimension score of pulmonary function indexes and quality of life were analyzed in SARS group.Data of hip and femoral head necrosis were detected by MRI scan in SARS group of patients.Results Total quality of life score was poor in 23 cases(92.0%),and moderate quality of life score in 2 cases(8.0%).The quality of life score was lower in SARS group than that of control group(P<0.01).Data of TLCOc SB was lower in SARS group than that of control group.The score of physiological function was positively correlated with FEV1 and FEVl/FVC.The score of physical pain was positively correlated with FEVl/FVC(P<0.05).There were no significant differences between quality of life score and pulmonary function indicators.There were 11 cases(44%) of avascular necrosis of femoral head,and 14 cases(56%) of non-avascular necrosis of femoral head in SARS group.The score of physiological function was lower in femoral head necrosis group than that of non necrosis group(P<0.05).Conclusion The lower quality of life in patients with SARS is not only related with psychological factors but also related with physical factors.The damage of pulmonary function and(or) necrosis of femoral head affect the quality of life in patients with SARS,especially the physiological function.
Objective To analyse the quality of life in patients with severe acute respiratory syndrome(SARS) for 10 years.Methods Twenty-five SARS patients were collected as SARS group and 25 healthy persons were used as control group.There were no significant differences in general clinical data between two groups.The quality of life of the respondents was evaluated by the MOS item short form health survey(SF- 36) including physiological function,physical pain,general health condition,energy,social function,emotional function and mental health.The pulmonary function indicators including forced vital capacity(FVC),one second forced expiratory volume(FEV1),one second rate(FEVl/FVC),total lung capacity(TLC),residual volume(RV),corrected breath diffusing capacity(TLCOc SB) and corrected dispersion rate TLCOc/VA were also compared between two groups.The correlation between each dimension score of pulmonary function indexes and quality of life were analyzed in SARS group.Data of hip and femoral head necrosis were detected by MRI scan in SARS group of patients.Results Total quality of life score was poor in 23 cases(92.0%),and moderate quality of life score in 2 cases(8.0%).The quality of life score was lower in SARS group than that of control group(P<0.01).Data of TLCOc SB was lower in SARS group than that of control group.The score of physiological function was positively correlated with FEV1 and FEVl/FVC.The score of physical pain was positively correlated with FEVl/FVC(P<0.05).There were no significant differences between quality of life score and pulmonary function indicators.There were 11 cases(44%) of avascular necrosis of femoral head,and 14 cases(56%) of non-avascular necrosis of femoral head in SARS group.The score of physiological function was lower in femoral head necrosis group than that of non necrosis group(P<0.05).Conclusion The lower quality of life in patients with SARS is not only related with psychological factors but also related with physical factors.The damage of pulmonary function and(or) necrosis of femoral head affect the quality of life in patients with SARS,especially the physiological function.
引文
[1]World Health Organization.Severe acute respiratory syndrome(SARS):over 100 days into the outbreak[J].Wkly Epidemiol Rec,2003,78(26):217-220.
[2]General Office of the Ministry of public health of the people's Republic of China.Criteria for the diagnosis of infectious atypical pneumonia CS3[S].Ministry of Health of the PRC,2003-05-03.[中华人民共和国卫生部办公厅.传染性非典型肺炎临床诊断标准CS3[S].中华人民共和国卫生部,2003-05-03].
[3]Ware J,Gandek B.Overview of SF-36 health survey and the international quality of life assessment(IQOLA)project[J].Clin Epidemiol,1998,51(11):903-912.doi:10.1016/S0895-4356(98)00081-X.
[4]American Thoracic Society.Evaluation of pairment/disability secondary to respiratory disorders[J].Am Rev Respir Dis,1986,133(6):1205-1209.
[5]Ministry of Public Health of the People's Republic of China.WS286-2008,Criteria for the diagnosis of infectious atypical pneumonia:the health industry standard of the people's Republic of China[S].2008.[中华人民共和国卫生部.传染性非典型肺炎诊断标准(WS286-2008):中华人民共和国卫生行业标准[S].2008].
[6]Ma LY,Sun X,Wu Q,et al.Laboratory analysis in patients with severe acute respiratory syndrome after ten years of convalescence in Tianjin[J].Tianjin Med J,2016,44(9):1102-1104.[马龙艳,孙昕,吴琦,等.天津地区感染SARS患者康复10年后化验指标随访分析[J].天津医药,2016,44(9):1102-1104].doi:10.11958/20150390.
[7]Ma RH,Fu L,Ma XT,et al.Research status of quality of life measurement scale and its specific modules[J].Nursing Journal of Chinese People's Liberation Army,2008,25(19):33-35.[马瑞珩,付立,马兴涛,等.生命质量测定量表及其特异性模块的研究现状[J].解放军护理杂志,2008,25(19):33-35].doi:10.3969/j.issn.1008-9993.2008.19.014.
[8]Du XF.Literature review of domestic life quality research in recent years[J].Industrial&Science Tribune,2015,2:122-125.[杜雪霏.近年来国内生命质量研究文献述评[J].产业与科技论坛,2015,2:122-125].doi:10.3969/j.issn.1673-5641.2015.02.061.
[9]Gomersall CD,Chan DP,Leung P,et al.Long term outcome of acute respiratory distress syndrome caused by severe acute respiratory syndrome(SARS):an observational study[J].Critical Care and Resuscitation,2006,8(4):302.
[10]Hui DS,Joynt GM,Wong KT,et al.Impact of severe acute respiratory syndrome(SARS)on pulmonary function,functional capacity and quality of life in a cohort of survivors[J].Thorax,2005,60(5):401-409.doi:10.1136/thx.2004.030205.
[11]Zhong JX,Chen YH,Zhu M,et al.The quality of life of patients cured and discharged alter one year of treatment in SARS patients[J].Henan Traditional Chinese Medicine,2004,24(10):18-20.[钟嘉熙,陈银环,朱敏,等.SARS患者治愈出院一年后生存质量追踪[J].河南中医,2004,24(10):18-20].
[12]Ngai JC,Ko FW,Ng SS,et al.The long-term impact of severe acute respiratory syndrome on pulmonary function,exercise capacity and health status[J].Respirology,2010,15(3):543-550.doi:10.1111/j.1440-1843.2010.01720.x.
[13]Li L,Sun X,Wu Q,et al.The lung function status in patients with severe acute respiratory syndrome after ten years of convalescence in Tianjin[J].Chinese Journal of Tuberculosis and Respiratory Diseases,2015,38(8):575-578.[李莉,孙昕,吴琦,等.天津地区严重急性呼吸综合征患者康复10年后肺功能状态[J].中华结核和呼吸杂志,2015,38(8):575-578].doi:10.3760/cma.j.issn.1001-0939.2015.08.005.
[14]Huang Q,Li W,Zhang H,et al.Assessment of health related quality of life in patients after total hip arthroplasty[J].Orthopedic Journal of China,2007,15(6):415-417.[黄强,李伟,张晖,等.全髋关节置换术后患者健康相关生存质量评估[J].中国矫形外科杂志,2007,15(6):415-417].
[2]General Office of the Ministry of public health of the people's Republic of China.Criteria for the diagnosis of infectious atypical pneumonia CS3[S].Ministry of Health of the PRC,2003-05-03.[中华人民共和国卫生部办公厅.传染性非典型肺炎临床诊断标准CS3[S].中华人民共和国卫生部,2003-05-03].
[3]Ware J,Gandek B.Overview of SF-36 health survey and the international quality of life assessment(IQOLA)project[J].Clin Epidemiol,1998,51(11):903-912.doi:10.1016/S0895-4356(98)00081-X.
[4]American Thoracic Society.Evaluation of pairment/disability secondary to respiratory disorders[J].Am Rev Respir Dis,1986,133(6):1205-1209.
[5]Ministry of Public Health of the People's Republic of China.WS286-2008,Criteria for the diagnosis of infectious atypical pneumonia:the health industry standard of the people's Republic of China[S].2008.[中华人民共和国卫生部.传染性非典型肺炎诊断标准(WS286-2008):中华人民共和国卫生行业标准[S].2008].
[6]Ma LY,Sun X,Wu Q,et al.Laboratory analysis in patients with severe acute respiratory syndrome after ten years of convalescence in Tianjin[J].Tianjin Med J,2016,44(9):1102-1104.[马龙艳,孙昕,吴琦,等.天津地区感染SARS患者康复10年后化验指标随访分析[J].天津医药,2016,44(9):1102-1104].doi:10.11958/20150390.
[7]Ma RH,Fu L,Ma XT,et al.Research status of quality of life measurement scale and its specific modules[J].Nursing Journal of Chinese People's Liberation Army,2008,25(19):33-35.[马瑞珩,付立,马兴涛,等.生命质量测定量表及其特异性模块的研究现状[J].解放军护理杂志,2008,25(19):33-35].doi:10.3969/j.issn.1008-9993.2008.19.014.
[8]Du XF.Literature review of domestic life quality research in recent years[J].Industrial&Science Tribune,2015,2:122-125.[杜雪霏.近年来国内生命质量研究文献述评[J].产业与科技论坛,2015,2:122-125].doi:10.3969/j.issn.1673-5641.2015.02.061.
[9]Gomersall CD,Chan DP,Leung P,et al.Long term outcome of acute respiratory distress syndrome caused by severe acute respiratory syndrome(SARS):an observational study[J].Critical Care and Resuscitation,2006,8(4):302.
[10]Hui DS,Joynt GM,Wong KT,et al.Impact of severe acute respiratory syndrome(SARS)on pulmonary function,functional capacity and quality of life in a cohort of survivors[J].Thorax,2005,60(5):401-409.doi:10.1136/thx.2004.030205.
[11]Zhong JX,Chen YH,Zhu M,et al.The quality of life of patients cured and discharged alter one year of treatment in SARS patients[J].Henan Traditional Chinese Medicine,2004,24(10):18-20.[钟嘉熙,陈银环,朱敏,等.SARS患者治愈出院一年后生存质量追踪[J].河南中医,2004,24(10):18-20].
[12]Ngai JC,Ko FW,Ng SS,et al.The long-term impact of severe acute respiratory syndrome on pulmonary function,exercise capacity and health status[J].Respirology,2010,15(3):543-550.doi:10.1111/j.1440-1843.2010.01720.x.
[13]Li L,Sun X,Wu Q,et al.The lung function status in patients with severe acute respiratory syndrome after ten years of convalescence in Tianjin[J].Chinese Journal of Tuberculosis and Respiratory Diseases,2015,38(8):575-578.[李莉,孙昕,吴琦,等.天津地区严重急性呼吸综合征患者康复10年后肺功能状态[J].中华结核和呼吸杂志,2015,38(8):575-578].doi:10.3760/cma.j.issn.1001-0939.2015.08.005.
[14]Huang Q,Li W,Zhang H,et al.Assessment of health related quality of life in patients after total hip arthroplasty[J].Orthopedic Journal of China,2007,15(6):415-417.[黄强,李伟,张晖,等.全髋关节置换术后患者健康相关生存质量评估[J].中国矫形外科杂志,2007,15(6):415-417].
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |