Practical synthesis of fully protected globotriaose and its glycopolymers
- 作者：Koji Matsuoka ; Yusuke Goshu ; Yutaka Takezawa ; Tomonori Mori ; Jun-Ichi Sakamoto ; Akihiro Yamada ; Tomotsune Onaga ; Tetsuo Koyama ; Ken Hatano ; Philip W. Snyder ; et al.
- 关键词：Globotriaose ; Glycosides ; Polymerization ; Glycoclusters ; Glycopolymers
- 刊名：Carbohydrate Polymers
- 出版年：2007
- 期刊代码：14_01448617
- 类别：ch
- 出版时间：1 June 2007
- 卷：69
- 期：2
- 页码：326-335
- 文件大小：299 K
摘要
Convenient and useful construction of a trisaccharide moiety of globotriaosyl ceramide was performed by means of modified Ogawa’s protocol. In order to evaluate an efficiency of new class of glycopolymers, further chemical transformations of the trisaccharide were accomplished to afford a globotriaosyl carbohydrate monomer, and homopolymerization of the monomer by a general radical polymerization protocol gave a high-density glycopolymer in 84.3%yield after usual work-up procedures. In addition to the homopolymer, a copolymer composed of carbohydrate units and acrylamide units was also synthesized by the radical polymerization in 96.7%yield.