Virus-derived anti-inflammatory proteins: potential therapeutics for cancer

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• 作者：Donghang Zheng¹ ; Hao Chen¹ ; Mee Y. Bartee¹ ; Jennifer Williams¹ ; ² ; Jennifer A. Davids¹ ; Emina Huang³ ; Jan Moreb⁴ ; Alexandra Lucas¹ ; ^{alexandra.lucas@medicine.ufl.edu}
• 关键词：cancer therapy ; inflammation ; viral serpins ; Serp-1 ; chemokine-binding proteins ; M-T7 ; M-T1
• 刊名：Trends in Molecular Medicine
• 出版年：2012
• 期刊代码：259_14714914
• 类别：med
• 出版时间：June, 2012
• 卷：18
• 期：6
• 页码：304-310
• 文件大小：980 K

摘要

Inflammatory responses now have a defined central role in cancer cell growth, invasion, and metastases. Anti-inflammatory proteins from viruses target key stages in immune response pathways and have potential as novel therapeutics for cancer, including highly potent virus-derived inhibitors of protease, chemokine, cytokine, and apoptotic cascades that have been identified. Serine proteases, in addition to their conventional roles in thrombosis, thrombolysis, and apoptotic pathways, are essential regulators of inflammation and are associated with developing cancers. Chemokines drive other inflammatory response pathways with central roles in cell invasion and activation as well as establishing the microenvironment of tumors, modulating immune cell infiltration, cancer cell proliferation, metastasis, and angiogenesis. This review focuses on the mechanisms of action and potential for application of viral immunomodulatory proteins as anticancer therapeutics.