- 作者：Marí ; a Dolores Martí ; nez del Valle Torres ; mariad.martinezvalle.sspa@juntadeandalucia.es ; Esperanza Ramos Moreno ; Tomader Amrani Raissouni ; Simeó ; n J. Ortega Lozano ; Salomé ; Sanz Viedma ; José ; Manuel Jimé ; nez-Hoyuela
- 关键词：Tomografí ; a computarizada por emisió ; n de positrones de fotó ; n ú ; nico ; Transportadores de dopamina ; Parkinsonismo ; Atrofia multisisté ; mica
- 刊名：Medicina Cl铆nica
- 出版年：2011
- 期刊代码：pca254_00257753
- 类别：med
- 出版时间：15 October 2011
- 卷：137
- 期：10
- 页码：440-443
- 文件大小：168 K
Background and objective
To assess the functional state of nigro-striatal pathway using FP-CIT-I-123 in patients with clinical diagnosis of Multiple System Atrophy (MSA) subtype C.
Patients and methods
We included 10 patients with a clinical diagnosis of MSA-C and compared them with 10 patients diagnosed with essential tremor (controls) and 10 with Parkinson Disease (PD). The studies are evaluated by the striatum/occipital index (S/O). We calculated the diagnostic validity of the procedure by ROC curve analysis.
Results
The average value of the S/O index showed a mean of 1.48 (0.23), 1.59 (0.17) and 1.22 (0.16) respectively for MSA-C, control group (p = 0.25) and PD (p = 0.00). ROC curve analysis: Az: 0.650; sensitivity: 0.50; specificity: 0.80. The comparison between the results of FP-CIT and clinical manifestations showed: 4 patients with parkinsonism (PK) and pathological study; 4 without PK and normal study; 1 with PK and normal study and 1 without PK and pathological study.
Conclusions
FP-CIT study does not exclude completely the existence of an MSA-C. From a functional point of view, there does not always seem to be a consistency between the state of the nigro-striatal pathway and the existence of parkinsonism.