Src-family protein tyrosine kinase negatively regulates cerebellar long-term depression

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• 作者：Shun Tsuruno ; Shin-ya Kawaguchi ; Tomoo Hirano
• 关键词：Purkinje neuron ; Cerebellum ; Synaptic plasticity ; LTD ; Src-family protein tyrosine kinase ; mGluR1
• 刊名：Neuroscience Research
• 出版年：2008
• 期刊代码：53_01680102
• 类别：neu
• 出版时间：July 2008
• 卷：61
• 期：3
• 页码：329-332
• 文件大小：173 K

摘要

Protein phosphorylation is a major mechanism for the regulation of synaptic transmission. Previous studies have shown that several serine/threonine kinases are involved in the induction of long-term depression (LTD) at excitatory synapses on a Purkinje neuron (PN) in the cerebellum. Here, we show that Src-family protein tyrosine kinases (SFKs) are involved in the regulation of the LTD induction. Intracellular application of c-Src suppressed LTD. We also show that application of a SFK-selective inhibitor PP2 recovered LTD from the suppression caused by the inhibition of mGluR1 activity. These results indicate that SFKs negatively regulate the LTD induction at excitatory synapses on a cerebellar PN.