ITN protection, MSP1 antibody levels and malaria episodes in young children of rural Burkina Faso

详细信息	查看全文 | 推荐本文 |

• 作者：Gisela Kynast-Wolf^a ; ¹ ; ^{gisela.kynast-wolf@urz.uni-heidelberg.de} ; Wieda Wakilzadeh^a ; ¹ ; Boubacar Coulibaly^b ; Paul Schnitzler^c ; Corneille Traoré ; ^d ; Heiko Becher^a ; Olaf Mü ; ller^a
• 关键词：Africa ; Burkina Faso ; Infants ; MSP1 antibodies ; Insecticide-treated mosquito nets ; Malaria ; Season
• 刊名：Acta Tropica
• 出版年：2012
• 期刊代码：2_0001706x
• 类别：imm
• 出版时间：August, 2012
• 卷：123
• 期：2
• 页码：117-122
• 文件大小：411 K

摘要

Malaria blood-stage vaccines are in an early phase of clinical development with MSP1 being a major antigen candidate. There are limited data on the protective efficacy of antibodies against subunits of MSP1 in the malaria endemic areas of sub-Saharan Africa. This prospective cohort study was nested into a large insecticide-treated mosquito net (ITN) trial during which neonates were individually randomised to ITN protection from birth vs. protection from month six onwards in rural Burkina Faso. A sub sample of 120 children from three villages was followed for 10 months with six measurements of MSP1₄₂ antibodies (ELISA based on recombinant 42 kDa fragment) and daily assessment of malaria episodes. Time to the next malaria episode was determined in relation to MSP1₄₂ antibody titres. MSP1₄₂ antibody titres were dependent on age, season, ITN-group, number of previous malaria episodes and parasitaemia. There were no significant differences in time until the next malaria episode in children with low compared to children with high MSP1₄₂ antibody titres at any point in time (101 vs. 97 days in May, p = 0.6; 58 vs. 84 days in September, p = 0.3; 144 vs. 161 days in March, p = 0.5). The findings of this study support the short-lived nature of the humoral immune response in infants of malaria endemic areas. The study provides no evidence for antibodies against a subunit of MSP1 being protective against new malaria episodes in infants.