Makomotindoline from Makomotake, Zizania latifolia infected with Ustilago esculenta

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• 作者：Tomohiro Suzuki^a ; ^&dagger ; ; Jae-Hoon Choi^a ; ^&dagger ; ; Takumi Kawaguchi^b ; Kimiko Yamashita^a ; Akio Morita^b ; Hirofumi Hirai^b ; Kaoru Nagai^c ; Tomoyasu Hirose^d ; Satoshi 艑mura^d ; Toshiaki Sunazuka^d ; ^{sunazuka@lisci.kitasato-u.ac.jp} ; Hirokazu Kawagishi^a ; ^b ; ^{achkawa@ipc.shizuoka.ac.jp}
• 关键词：Makomotake ; Ustilago esculenta ; Structure determination ; Glioma cell ; Synthesis
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 July, 2012
• 卷：22
• 期：13
• 页码：4246-4248
• 文件大小：447 K

摘要

Makomotindoline (1) was isolated from Makomotake, Zizania latifolia infected with Ustilago esculenta. The structure was determined by the interpretation of spectroscopic data and synthesis. Makomotindoline (1), its l-Glc isomer (2) and its aglycon (3) were synthesized and their effects on rat glioma cells showed adverse effects on the cell growth.