Multi-scaled polymersomes from self-assembly of octadecanol-modified dextrans

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• 作者：Wen-Hsuan Chiang^a ; Yu-Jen Lan^b ; Yun-Chiao Huang^b ; Yu-Wen Chen^b ; Yi-Fong Huang^b ; Sung-Chyr Lin^b ; Chorng-Shyan Chern^c ; Hsin-Cheng Chiu^a ; ^{hscchiu@mx.nthu.edu.tw}
• 关键词：Lipid-modified dextran ; Supramolecular assembly ; Polymersomes
• 刊名：Polymer
• 出版年：2012
• 期刊代码：83_00323861
• 类别：ms
• 出版时间：9 May, 2012
• 卷：53
• 期：11
• 页码：2233-2244
• 文件大小：1507 K

摘要

Lipid-conjugated polysaccharide vesicles in nano- and micro-scale were developed from amphiphilic octadecanol-modified dextrans (OMD) prepared by partial esterification of dextran with activated octadecanol-carbamate imidazole in a well-controlled manner. The critical aggregation concentration (CAC) of OMD adducts in aqueous phase varies, depending mainly on their octadecanol contents. Through supramolecular assembly of the OMD adducts comprising either 17 or 28聽mol%octadecanol residues with respect to the anhydroglucopyranose units by the partial solvent displacement technique with the initial water content of DMSO/H₂O solutions beyond a critical point, stable nano-scaled OMD assemblies were developed and characterized by the vesicle-like morphology. The dimension of polymersomes can be effectively controlled by the OMD composition as well as the initial water content. On the other hand, micro-scaled OMD polymersomes can be achieved by the double emulsion technique in a water/oil/water (w₁/o/w₂) manner. Both the contents of NaCl in aqueous solution as the w₁ phase and of DMSO in DMSO/CHCl₃ co-solvents as the organic phase, in which OMD was dissolved, are of great importance in controlling the polymersome morphology and size. These micro-scaled OMD polymersome walls are characterized by size-selective permeability capable of encapsulating large water-soluble cargoes while allowing transport of small polar species across the membrane, thereby rendering these unique colloidal particles of potential applications in biomedical technologies.