Template synthesis, spectroscopic characterization and preliminary insulin-mimetic activity of oxovanadium(IV) complexes with Nb>2b>Ob>2b> diazadioxa macrocycles

详细信息	查看全文 | 推荐本文 |

• 作者：M.L. Sharma ; S.K. Sengupta ; O.P. Pandey ; ^{oppandey1658@yahoo.com}
• 关键词：Oxovanadium(IV) ; Macrocyclic ; Triazoles ; EPR ; Insulin-mimetic ; XRD
• 刊名：Spectrochimica Acta Part A ; Molecular and Biomolecular Spectroscopy
• 出版年：2012
• 期刊代码：99_13861425
• 类别：ch
• 出版时间：September, 2012
• 卷：95
• 期：Complete
• 页码：562-568
• 文件大小：593 K

摘要

A new series of diazadioxa oxovanadium(IV) macrocyclic complexes of type [VO(mac)]SOb>4b> have been synthesized via the condensation reaction of a 3-(phenyl/substituted phenyl)-4-amino-5-hydrazino-1,2,4-triazole (Hb>2b>L) with salicylaldehyde/2-hydroxyacetophenone and 1,4-dibromobutane in the presence of oxovanadium(IV) sulfate in ethanol. All the newly synthesized compounds were characterized on the basis of elemental analyses, conductance measurements, magnetic properties, spectral (UV-Vis, IR, EPR) and XRD studies. The particle size of the complexes has been calculated from XRD spectra using Debye-Scherrer formula and these are found to be in 31-32 nm range. The efficacy of two macrocyclic complexes was also studied in streptozotocin-induced diabetic rats over a period of 30 days. The administration of these complexes in diabetic rats reversed the diabetic effect due to their insulin-mimetic effects.