IRT was measured using AutoDELFIA Neonatal IRT-Kit in stored NBS cards.
Between 2006 and 2009, 66 children with CF were reported, 4 of which were excluded for various reasons (born in another country, NBS at 6 months, no informed consent). 98%(61/62) had significantly higher IRT compared to matched control group. There was one false negative IRT result in an asymptomatic child with atypical CF (normal pancreatic function and sweat test).
All children but one with atypical CF would have been detected with the planned two step protocol.
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