Br枚nsted acid hydrotrope combined catalyst for environmentally benign synthesis of quinoxalines and pyrido[2,3-b]pyrazines in aqueous medium

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• 作者：Arjun Kumbhar ; Santosh Kamble ; Madhuri Barge ; Gajanan Rashinkar ; Rajashri Salunkhe ; ^{rss234@rediffmail.com}
• 关键词：Pyrido[2 ; 3-b]pyrazines ; Quinoxalines ; Brö ; nsted acid hydrotrope combined catalyst (BAHC) ; Catalyst recycling ; Aqueous medium
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：30 May, 2012
• 卷：53
• 期：22
• 页码：2756-2760
• 文件大小：2742 K

摘要

A new Br枚nsted acid hydrotrope combined catalyst (BAHC) has been developed and applied in acid catalyzed synthesis of pyrido[2,3-b]pyrazines and quinoxalines in an aqueous medium at ambient temperature with excellent yields. Interestingly, the catalyst can be easily recovered after the reactions and reused. Furthermore, BAHC catalyst worked well and avoids the use of organic solvents. We have reported herein the synthetic pathway which has less disastrous effect in the atmosphere and human survival.