Kanamycin A 6鈥?pyrenylamide: a selective probe for heparin detection

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• 作者：Santosh V. Nalage^a ; Sidhanath V. Bhosale^a ; ^c ; ^{sidhanath.bhosale@gmail.com} ; Suresh K. Bhargava^b ; Sheshanath V. Bhosale^b ; ^{bsheshanath@gmail.com}
• 关键词：Biosensor ; Heparin ; Aminoglycoside ; Pyrene ; Fluorescence ; UV&ndash ; vis spectroscopy
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：6 June, 2012
• 卷：53
• 期：23
• 页码：2864-2867
• 文件大小：494 K

摘要

We have synthesized a novel derivative of kanamycin A bearing a pyrenyl fluorophore which can be used for the specific recognition of heparin in EtOH:H₂O (1:3) through formation of a 2:1 complex. The receptor shows specific optical signalling for heparin, but exhibits no significant changes on addition of various other biological molecules.