Induction of an adaptive response in human blood lymphocytes exposed to radiofrequency fields: Influence of the universal mobile telecommunication system (UMTS) signal and the specific absorption rate

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• 作者：Olga Zeni^a ; Anna Sannino^a ; ^b ; Stefania Romeo^a ; ^c ; Rita Massa^a ; ^d ; Maurizio Sarti^a ; ¹ ; Abishek B. Reddy^e ; Thomas J. Prihoda^f ; Vijayalaxmi^e ; Maria Rosaria Scarfì ; ^a ; ^{scarfi.mr@irea.cnr.it}
• 关键词：Adaptive response ; Radiofrequency fields ; UMTS signal ; Specific absorption rate ; Human blood lymphocytes ; Micronuclei
• 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
• 出版年：2012
• 期刊代码：31_13835718
• 类别：pha
• 出版时间：30 August, 2012
• 卷：747
• 期：1
• 页码：29-35
• 文件大小：366 K

摘要

The induction of an adaptive response (AR) was examined in human peripheral blood lymphocytes exposed to non-ionizing radiofrequency fields (RF). Cells from nine healthy human volunteers were stimulated for 24 h with phytohaemagglutinin and then exposed for 20 h to an adaptive dose (AD) of a 1950 MHz RF UMTS (universal mobile telecommunication system) signal used for mobile communications, at different specific absorption rates (SAR) of 1.25, 0.6, 0.3, and 0.15 W/kg. This was followed by treatment of the cells at 48 h with a challenge dose (CD) of 100 ng/ml mitomycin C (MMC). Lymphocytes were collected at the end of the 72 h total culture period. The cytokinesis-block method was used to record the frequency of micronuclei (MN) as genotoxicity end-point. When lymphocytes from six donors were pre-exposed to RF at 0.3 W/kg SAR and then treated with MMC, these cells showed a significant reduction in the frequency of MN, compared with the cells treated with MMC alone; this result is indicative of induction of AR. The results from our earlier study indicated that lymphocytes that were stimulated for 24 h, exposed for 20 h to a 900 MHz RF GSM (global system for mobile communication) signal at 1.25 W/kg SAR and then treated with 100 ng/ml MMC, also exhibited AR. These overall data suggest that the induction of AR depends on RF frequency, type of the signal and SAR. Further characterization of RF-induced AR is in progress.