Residual disability 10 years after falling ill in Guillain-Barr茅 syndrome: A prospective follow-up study

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• 作者：Anette Forsberg^a ; ^b ; ^{anette.forsberg@orebroll.se} ; Rayomand Press^a ; ^c ; Lotta Widé ; n Holmqvist^a ; ^d
• 关键词：Guillain&ndash ; Barré ; syndrome ; Erasmus GBS outcome score ; Prospective study ; Recovery of function
• 刊名：Journal of the Neurological Sciences
• 出版年：2012
• 期刊代码：178_0022510x
• 类别：med
• 出版时间：15 June, 2012
• 卷：317
• 期：1-2
• 页码：74-79
• 文件大小：362 K

摘要

Objective

To describe residual disability 10 years after onset of Guillain-Barr茅 syndrome (GBS) and longitudinal changes from 2 weeks after onset until 10 years afterwards. The Erasmus GBS Outcome score (EGOS) was applied for predicting prognosis at 2 and 10 years.

Methods

Twenty-nine patients, mean age at onset 49 years, were followed prospectively from 2 weeks to 10 years after GBS onset. Measures included; GBS disability score, EGOS, Barthel Index, Frenchay Activity Index, Sickness Impact Profile (SIP), Overall Neuropathy Limitations Scale (ONLS), Walk-12, and Fatigue Severity Scale.

Results

At 10 years, the facial paralysis found in 5 participants at 2 years was still present, 11 participants (38%) experienced paresthesia, 6 (21%) had limitations in their arms, and 15 (52%) had limitations in walking. Decreased health-related quality of life on comparison to the general population was seen in the physical dimension of SIP at 10 years. The median EGOS at 2 weeks was 4.5, which correlated highly only with the Barthel Index at 2 years and the ONLS arm scale at 10 years.

Conclusion

The residual disabilities at 1-2 years comprised mainly of reduced walking ability, and are still persistent 10 years after GBS onset. For some individuals, facial paralysis caused major disability. The EGOS only partly predicted residual disability at 2 and 10 years after onset.