Association of transforming growth factor beta-1 (TGFB1) regulatory region polymorphisms with myasthenia gravis-related ophthalmoparesis

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• 作者：M.V. Akinyi^a ; C. Dandara^b ; J. Gamieldien^c ; J.M. Heckmann^a ; ^{Jeanine.heckmann@uct.ac.za}
• 关键词：Myasthenia gravis ; Ophthalmoplegia ; Extraocular muscles ; Single nucleotide polymorphisms ; Transforming growth factor beta-1 ; African
• 刊名：Journal of Neuroimmunology
• 出版年：2012
• 期刊代码：32_01655728
• 类别：neu
• 出版时间：15 May, 2012
• 卷：246
• 期：1-2
• 页码：96-99
• 文件大小：266 K

摘要

We investigated the association of an ophthalmoplegic complication developing in African myasthenia gravis (MG) subjects with polymorphisms in the regulatory region of TGFB1. We found significant associations with several putative functional single nucleotide polymorphisms (SNPs) (including two novel SNPs) that potentially alter transcription factor binding. Our data support a hypothesis that altered TGFB1 regulation may predispose individuals who harbour these SNPs to developing ophthalmoplegia as a result of increased TGF-尾1 driven myofibrosis as a consequence to complement-mediated damage.