Prostaglandins E₁ and E₂ inhibit lipopolysaccharide-induced interleukin-18 production in monocytes

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• 作者：Hideo K. Takahashi ; Hiromi Iwagaki ; Shuji Mori ; Tadashi Yoshino ; Noriaki Tanaka and Masahiro Nishibori
• 关键词：Prostaglandin ; Monocyte ; Adhesion molecule
• 刊名：European Journal of Pharmacology
• 出版年：2005
• 期刊代码：24_00142999
• 类别：neu
• 出版时间：2005
• 卷：517
• 期：3
• 页码：252-256
• 文件大小：238 K

摘要

The purpose of this present study was to explore the therapeutic potential of prostaglandins E₁ and E₂ on the systemic inflammatory response evoked by endotoxin. Since interleukin-18, a monocyte-derived cytokine, is increased during sepsis, decreasing the production of interleukin-18 is important in treating this condition. Prostaglandin E₁ and E₂ inhibited interleukin-18 production in human monocytes treated with lipopolysaccharide and prostanoid IP-, EP₂- and EP₄-receptor agonists mimicked the effects of prostaglandins E₁ and E₂. Therefore, prostanoid IP, EP2- and EP4-receptors might be involved in the decrease in interleukin-18 production during sepsis.