Prepubertal chronic ethanol administration alters TTF-1 and Oct-2 expression in the hypothalamus of female rats

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• 作者：Kim ; Hyun Joon ; Sohn ; Hyun Joon ; Ha ; Myung ; Han ; Jae Yoon ; Kang ; Sang Soo ; Choi ; Wan Sung ; Cho ; Gyeong Jae
• 刊名：Molecular Brain Research
• 出版年：2005
• 期刊代码：40_0169328x
• 类别：neu
• 出版时间：May 20, 2005
• 卷：136
• 期：1-2
• 页码：262-266
• 文件大小：326 K

摘要

We found that prolonged administration of ethanol (3 g/kg i.p. at 08:00, once per day) to young female rats starting on postnatal day 24 caused delayed puberty. We further found that prolonged ethanol administration changed the typical hypothalamic expression patterns of TTF-1 and Oct-2 and reduced GnRH mRNA expression. We suggest that these changes may cause the ethanol-induced disturbances in the regulation of GnRH in the hypothalamus and may be responsible for the ethanol-induced reduction in GnRH and LH associated with delayed puberty.