Dietary restriction increases site-specific histone H3 acetylation in rat liver: Possible modulation by sirtuins

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• 作者：Kyojiro Kawakami^a ; Akihiro Nakamura^b ; Sataro Goto^a ; ^{gotosataro@sakura.juntendo.ac.jp}
• 关键词：Dietary (calorie) restriction ; Aging ; Histone modification ; Acetylation ; Epigenetics ; Sirtuin
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2012
• 期刊代码：159_0006291x
• 类别：bio
• 出版时间：24 February, 2012
• 卷：418
• 期：4
• 页码：836-840
• 文件大小：284 K

摘要

We studied dietary restriction (DR) related changes of site-specific acetylation of histone H3 in rat livers to explore a possible link to histone modifications and sirtuin levels with anti-aging effects of DR. The acetylation at lysine residue 9, 27 and 56 in H3 was 20-30%higher in DR animals compared with ad libitum fed counterparts. SIRT6, one of histone deacetylases, was significantly decreased by DR and thereby may be involved in an increase in the histone acetylation. Our findings suggest that upregulation of chromatin activities through increased histone acetylation is a mechanism of anti-aging effects of DR.