• 作者：Laia Martí ; Malgosa ; ^{lmarti@tauli.cat} ; Belé ; n Cochs Cosme ; Jordi Costa Pueyo ; Sandra Medina Argemí ; À ; gueda Rodrí ; guez Vicente ; Yolanda Canet Esté ; vez
• 关键词：Misoprostol ; Aborto de segundo trimestre ; Finalizació ; n de gestació ; n
• 刊名：Progresos de Obstetricia y Ginecolog铆a
• 出版年：2011
• 期刊代码：pca294_03045013
• 类别：med
• 出版时间：June 2011
• 卷：54
• 期：6
• 页码：300-305
• 文件大小：273 K

Objective

To compare the mean induction-expulsion times in two regimens of vaginal misoprostol for second-trimester pregnancy termination.

Material and methods

We performed a retrospective study of 281 pregnancies between January 2000 and December 2005 (regimen A: 800 渭g /24 h) and between June 2007 and December 2008 (regimen B: 400 渭g /4 h). Induction-expulsion time was taken as the main outcome.

Results

The mean expulsion time was similar in both regimens (19.7 h for A and 17.7 h for B). No significant differences were found in the expulsion rate at 12, 24 and 48 h. The most commonly observed adverse effect was fever, which was more frequent in regimen B. No major adverse effects such as uterine rupture or severe hemorrhage were observed.

Conclusions

No significant differences were found between regimens A and B in the mean fetal expulsion time, although fever was more common in regimen B.