Non-invasive continuous EEG-fNIRS recording of temporal lobe seizures

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• 作者：Dang Khoa Nguyen^a ; ^{d.nguyen@umontreal.ca} ; Julie Tremblay^b ; Philippe Pouliot^c ; Phetsamone Vannasing^b ; Olivia Florea^b ; Lionel Carmant^b ; Franco Lepore^d ; Mohamad Sawan^c ; Fré ; dé ; ric Lesage^c ; Maryse Lassonde^b ; ^d
• 关键词：EEG-fNIRS ; Seizures ; Haemodynamic response ; Temporal lobe epilepsy
• 刊名：Epilepsy Research
• 出版年：2012
• 期刊代码：87_09201211
• 类别：med
• 出版时间：March, 2012
• 卷：99
• 期：1-2
• 页码：112-126
• 文件大小：2304 K

摘要

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Summary

Purpose

Functional near-infrared spectroscopy (fNIRS) is a technique that allows continuous non-invasive monitoring of tissue oxygenation and haemodynamics in the brain. By using combined EEG-fNIRS recordings, we sought to better understand the pathophysiology of temporal lobe seizures.

Results

Nine patients (5 males; mean age 35 years; range 11-56 years) with refractory mesial temporal lobe epilepsy underwent combined EEG-fNIRS recordings. Eight complex partial seizures from 3 patients were successfully recorded. All seizures were associated with significant local and remote haemodynamic changes which outlasted the duration of seizures. Over the epileptogenic temporal lobe, increased oxygenation [increase in cerebral blood volume (CBV) and oxyhaemoglobin (HbO), decrease in deoxyhaemoglobin (HbR)] was followed by a deoxygenated state [increase in HbR]. A similar haemodynamic profile was seen over the contralateral temporal lobe (even without evidence of epileptic propagation) though variations generally had lower amplitudes. Heterogeneous haemodynamic changes in remote frontal and/or parietal areas were also noted early on when epileptic activity was limited to the temporal lobe.

Conclusion

EEG-fNIRS reveals complex local and remote oxygenation changes during temporal lobe seizures.