Micro- and nanostructured Al<sub>2sub>O<sub>3sub> surfaces for controlled vascular endothelial and smooth muscle cell adhesion and proliferation
- 作者：Cenk Aktas<sup>asup><sup> ; sup><sup>1sup><sup> ; sup><sup>cenk.aktas@inm-gmbh.desup> ; Eva Dö ; rrschuck<sup>bsup><sup> ; sup><sup>1sup> ; Cathrin Schuh<sup>bsup> ; Marina Martinez Miró ; <sup>asup> ; Juseok Lee<sup>asup> ; Norbert Pü ; tz<sup>csup> ; Gunther Wennemuth<sup>csup> ; Wolfgang Metzger<sup>dsup> ; Martin Oberringer<sup>dsup> ; Michael Veith<sup>asup><sup> ; sup><sup>esup> ; Hashim Abdul-Khaliq<sup>bsup>
- 关键词：Nanowires ; CVD ; Cells ; Biomaterial
- 刊名：Materials Science and Engineering ; C
- 出版年：2012
- 期刊代码：63_09284931
- 类别：ms
- 出版时间：1 July, 2012
- 卷：32
- 期：5
- 页码：1017-1024
- 文件大小：1433 K
摘要
The effect of the micro- and nanotopography on vascular cell-surface interaction is investigated using nano- and microstructured Al<sub>2sub>O<sub>3sub> as model substrate. Two different nanostructured Al<sub>2sub>O<sub>3sub> surfaces composed of low density (LD) and high density (HD) nanowires (NWs) were synthesized by chemical vapour deposition (CVD) and commercially available microstructured Al<sub>2sub>O<sub>3sub> plates were used for comparison. A clear diverging response of human umbilical vein endothelial cells (HUVEC) and human umbilical vein smooth muscle cells (HUVSMC) was observed on these nano- and microstructured surfaces. LD Al<sub>2sub>O<sub>3sub> NWs seem to enhance the proliferation of HUVECs selectively. This selective control of the cell-surface interaction by topography may represent a key issue for the future stent material design.