Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives

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• 作者：Francisco W.A. Barros^a ; Teresinha Gonç ; alves Silva^b ; Marina Galdino da Rocha Pitta^b ; Daniel P. Bezerra^c ; Letí ; cia V. Costa-Lotufo^a ; Manoel Odorico de Moraes^a ; Clá ; udia Pessoa^a ; Maria Aline F.B. de Moura^d ; Fabiane C. de Abreu^d ; Maria do Carmo Alves de Lima^b ; Suely Lins Galdino^b ; Ivan da Rocha Pitta^b ; ; Marilia O.F. Goulart^d ; ^{mofg@qui.ufal.br}
• 关键词：Acridine ; Thiazolidines ; Cytotoxicity ; DNA sensors
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2012
• 期刊代码：9_09680896
• 类别：ch
• 出版时间：1 June, 2012
• 卷：20
• 期：11
• 页码：3533-3539
• 文件大小：315 K

摘要

Although their exact role in controlling tumour growth and apoptosis in humans remains undefined, acridine and thiazolidine compounds have been shown to act as tumour suppressors in most cancers. Based on this finding, a series of novel hybrid 5-acridin-9-ylmethylene-3-benzyl-thiazolidine-2,4-diones were synthesised via N-alkylation and Michael reaction. The cell viability was analysed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and DNA interaction assays were performed using electrochemical techniques.