Nine hundred and sixty-nine MESA participants were genotyped and underwent CT examinations for coronary artery calcification (CAC) and carotid ultrasound examinations for intima media thickness. Genetic association analyses were performed.
The AA genotype was associated with a 2.4 mg/dl higher HDL-C, adjusting for age, gender, race/ethnicity and clinic site (<i>pi> = 0.04). There was a 28%lower prevalence of CAC (<i>pi> = 0.002) in those with AA genotype that persisted after further adjustment for HDL-C. There were no significant associations between −565 C/T genotype and HDL-C. There were trends towards a higher prevalence of CAC in those with CT (PR = 1.13, <i>pi> = 0.08) and TT (PR = 1.16, <i>pi> = 0.08) genotypes, compared with CC genotype. Neither G1051A nor −565C/T polymorphisms were associated with carotid intima media thickness.
The AA genotype of the G1051A polymorphism is associated with slightly higher HDL-C and lower prevalence of CAC and thus may protect against subclinical cardiovascular disease. The T allele of −565 C/T polymorphism may increase risk for subclinical cardiovascular disease.
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