- 作者：Jeana L. Benton ; Jingzhong Ding ; Michael Y. Tsai ; Steven Shea ; Jerome I. Rotter ; Gregory L. Burke ; Wendy Post
- 关键词：ABCA1 ; HDL cholesterol ; Coronary calcium ; Candidate genes ; Genetic polymorphisms ; Atherosclerosis
- 刊名：Atherosclerosis
- 出版年：2007
- 期刊代码：28_00219150
- 类别：med
- 出版时间：August 2007
- 卷：193
- 期：2
- 页码：352-360
- 文件大小：126 K
Methods
Nine hundred and sixty-nine MESA participants were genotyped and underwent CT examinations for coronary artery calcification (CAC) and carotid ultrasound examinations for intima media thickness. Genetic association analyses were performed.
Results
The AA genotype was associated with a 2.4 mg/dl higher HDL-C, adjusting for age, gender, race/ethnicity and clinic site (<i>pi> = 0.04). There was a 28%lower prevalence of CAC (<i>pi> = 0.002) in those with AA genotype that persisted after further adjustment for HDL-C. There were no significant associations between −565 C/T genotype and HDL-C. There were trends towards a higher prevalence of CAC in those with CT (PR = 1.13, <i>pi> = 0.08) and TT (PR = 1.16, <i>pi> = 0.08) genotypes, compared with CC genotype. Neither G1051A nor −565C/T polymorphisms were associated with carotid intima media thickness.
Conclusion
The AA genotype of the G1051A polymorphism is associated with slightly higher HDL-C and lower prevalence of CAC and thus may protect against subclinical cardiovascular disease. The T allele of −565 C/T polymorphism may increase risk for subclinical cardiovascular disease.