Diagnosis and treatment of vaginal intraepithelial neoplasia

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• 作者：Wei-Wei Wee^a ; ^{wcube@hotmail.com} ; Yin N. Chia^b ; Philip K.-L. Yam^c
• 关键词：Diagnosis ; Treatment ; Vaginal intraepithelial neoplasia
• 刊名：International Journal of Gynecology and Obstetrics
• 出版年：2012
• 期刊代码：130_00207292
• 类别：med
• 出版时间：April, 2012
• 卷：117
• 期：1
• 页码：15-17
• 文件大小：95 K

摘要

Objective

To audit our experience of the diagnosis and treatment of vaginal intraepithelial neoplasia (VAIN) in Kandang Kerbau Women's Hospital, Singapore.

Methods

The clinical records of the patients diagnosed as having VAIN at our institution in the calendar year 2009 were periodically reviewed until March 2011.

Results

There were 21 cases of VAIN. The mean follow-up duration was 18.2 months. The lesion grades were VAIN 1 in 9 patients (42.9%), VAIN 2 in 9 patients (42.9%), and VAIN 3 in 3 patients (14.3%). The mean patient age was 39.1 years. Sixteen patients (76.2%) were referred to our institution because of abnormal results to cytology tests and 4 patients (21.9%) were referred because of vaginal warts. The remaining patient was diagnosed from a surgical specimen. The diagnosis involved a cytology test, a colposcopic examination, an acetowhite test, a Schiller test, and a colposcopy-directed biopsy. The treatments varied and included watchful waiting but carbon dioxide laser vaporization was used the most frequently.

Conclusion

After 6 months of follow-up 18 patients were considered cured, for an overall cure rate of 85.7%. Two patients wanted no treatment and disease remained persistent in 1 patient despite laser vaporization and intravaginal applications of imiquimod cream.