Factors Related With the Higher Percentage of Hospitalizations Due to Asthma Amongst Women: The FRIAM Study

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• 作者：Carlos Melero Moreno^a ; Antol&iacute ; n Ló ; pez-Viñ ; a^b ; ^{alopezv@separ.es} ; Mercedes Garc&iacute ; a-Salmones Mart&iacute ; n^c ; Carolina Cisneros Serrano^d ; Javier Jareñ ; o Esteban^e ; Maria Teresa Ramirez Prieto^f ; Neumomadrid Asthma Group
• 关键词：Asthma ; Hospitalization ; Hyperventilation ; Sex
• 刊名：Archivos de Bronconeumolog&iacute ; a (English Edition)
• 出版年：2012
• 期刊代码：22_15792129
• 类别：med
• 出版时间：July, 2012
• 卷：48
• 期：7
• 页码：234-239
• 文件大小：377 K

摘要

Introduction

The reason why there is a higher hospitalization rate due to asthma exacerbations amongst women is unclear. The objective of this study is to explore the possible causes that may explain this fact.

Methods

A multi-center, prospective study including asthma patients hospitalized in the pulmonary medicine departments during a 2-year period.

By means of a questionnaire, the following data were collected: demographic characteristics and treatment compliance, anxiety-depression, hyperventilation and asthma control, both prior to and during the hospitalization.

Results

183 patients were included, 115 (62.84%) of whom were women. The women were older (52.4卤18.3/43.4卤18.7; P=.02), were more frequently prescribed inhaled corticosteroids (63.2%/47.1%; P=.03) and had a higher rate of hyperventilation syndrome (57.3/35.9; P=.02) and a longer mean hospital stay (7.3卤3.4/5.9卤3.6; P=.02). The percentage of smokers among the women was lower (21.2%/38.8%; P=.01) and the FEV₁ was lower at admittance (58.2%卤15.9%/67.5%卤17.4%; P=.03).

In the 40-60-year-old age range, an association was demonstrated between being female and the 鈥榩revious hospitalizations鈥?variable (OR, 16.1; 95%CI, 1.6-156.7); sex and obesity were also independently associated (OR, 4.8; 95%CI, 1.06-22).

Conclusions

In this cohort, the rate of hospitalization for asthma was higher in women than in men. Being a woman between the ages of 40 and 60 is associated with previous hospitalizations and is a risk factor for asthma-related hospitalization. This situation could partially be explained by the hormonal changes during menopause, where polyposis and obesity are independent risk factors.