Histochemical analyses of glycoconjugates and antimicrobial substances in goat labial glands

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• 作者：Isao Habata^a ; Tadashi Yasui^a ; Osamu Fujimori^b ; Wilfried Meyer^c ; Azuma Tsukise^a ; ^{tsukise@brs.nihon-u.ac.jp}
• 关键词：Labial glands ; Glycoconjugates ; Antimicrobial substances ; Histochemistry ; Goat
• 刊名：Acta Histochemica
• 出版年：2012
• 期刊代码：2_00651281
• 类别：bio
• 出版时间：September, 2012
• 卷：114
• 期：5
• 页码：454-462
• 文件大小：7302 K

摘要

Saliva is known to protect the oral cavity and contains glycoproteins and antimicrobial substances. The distribution of these salivary secretions was studied in the labial glands of the Japanese miniature (Shiba) goat using lectin histochemical and immunohistochemical methods. The mucous acinar cells of the labial glands exhibited glycoconjugates with different saccharide residues, such as GalNAc伪1-3GalNAc, Gal尾1-4GalNAc, 尾-d-GlcNAc and sialic acid linked to 伪2-6Gal/GalNAc. Furthermore, 伪-d-Man, 伪-l-Fuc, 伪-d-GalNAc, 尾-d-Gal and sialic acid residues were present, in particular, in the serous demilunar cells. Antimicrobial substances (lysozyme, IgA, lactoferrin and 尾-defensin) were shown to be mainly immunolocalized in the serous demilunes and duct cells. The results obtained are discussed with regard to the functional role of labial glands. The secretory compounds demonstrated may play an important role in the maintenance of oral health with regard to saliva.