Key challenges to the development of extracorporeal bioartificial liver support systems

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• 作者：Li-Fu Zhao ; Xiao-Ping Pan ; Lan-Juan Li ; ^{ljli@zju.edu.cn}
• 关键词：bioartificial liver ; liver failure ; cell source ; bioreactor
• 刊名：Hepatobiliary & Pancreatic Diseases International
• 出版年：2012
• 期刊代码：pca182_14993872
• 类别：med
• 出版时间：15 June, 2012
• 卷：11
• 期：3
• 页码：243-249
• 文件大小：133 K

摘要

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Background

For nearly three decades, extracorporeal bioartificial liver (BAL) support systems have been anticipated as promising tools for the treatment of liver failure. However, these systems are still far from clinical application. This review aimed to analyze the key challenges to the development of BALs.

Data Sources

We carried out a PubMed search of English-language articles relevant to extracorporeal BAL support systems and liver failure.

Results

Extracorporeal BALs face a series of challenges. First, an appropriate cell source for BAL is not readily available. Second, existing bioreactors do not provide in vivo-like oxygenation and bile secretion. Third, emergency needs cannot be met by current BALs. Finally, the effectiveness of BALs, either in animals or in patients, has been difficult to document.

Conclusions

Extracorporeal BAL support systems are mainly challenged by incompetent cell sources and flawed bioreactors. To advance this technology, future research is needed to provide more insights into interpreting the conditions for hepatocyte differentiation and liver microstructure formation.