HOMA-IR and non-HDL-C as predictors of high cholesteryl ester transfer protein activity in patients at risk for type 2 diabetes

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• 作者：R.I. Coniglio^a ; T. Meroñ ; o^b ; H. Montiel^a ; M.M. Malaspina^a ; A.M. Salgueiro^a ; J.C. Otero^a ; R. Ferraris^a ; L. Schreier^b ; F. Brites^b ; ^{fdbrites@hotmail.com} ; L. G&oacute ; mez Rosso^b
• 关键词：Metabolic syndrome ; Insulin Resistance ; Cholesteryl ester transfer protein ; Atherosclerosis ; Type 2 Diabetes ; Lipoproteins
• 刊名：Clinical Biochemistry
• 出版年：2012
• 期刊代码：55_00099120
• 类别：med
• 出版时间：May, 2012
• 卷：45
• 期：7-8
• 页码：566-570
• 文件大小：272 K

摘要

class="h4">Background and aims

Metabolic syndrome (MS) and type 2 diabetes are highly associated with an abnormal lipoprotein profile, which may be generated and accentuated by high cholesteryl ester transfer protein (CETP) activity. Given the difficulty in measuring CETP activity, the aim was to identify simple biochemical predictors of high CETP activity.

class="h4">Design and methods

Eighty five subjects at risk for type 2 diabetes were classified according to the presence of MS. Lipoprotein profile, HOMA-IR and endogenous CETP activity were evaluated.

class="h4">Results

As expected, MS patients presented higher concentration of glucose, insulin, triglycerides and non-HDL-C and lower HDL-C levels. Moreover, MS patients exhibited increased HOMA-IR and CETP activity. Employing a ROC curve for MS, high CETP activity was defined as > 250% ml^鈭?#xA0;1 h^鈭?#xA0;1. The predictive variables of high CETP were non-HDL-C 鈮?#xA0;160 mg/dl (OR = 11.1;95%IC = 3.3-38.2;p < 0.001) and HOMA-IR > 2.1 (OR = 4.4;95%IC = 1.3-14.8;p < 0.05).

class="h4">Conclusions

High non-HDL-C and insulin resistance were predictors for increased CETP activity which measurement is not accessible for clinical laboratories.