PAX5-AUTS2: A recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia

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• 作者：Dagmar Denk^a ; ¹ ; Karin Nebral^a ; ¹ ; Jutta Bradtke^b ; Gertrud Pass^c ; Anja Mö ; ricke^d ; Andishe Attarbaschi^e ; Sabine Strehl^a ; ^{sabine.strehl@ccri.at}
• 关键词：PAX5-AUTS2 ; Fusion transcript ; Childhood acute lymphoblastic leukemia
• 刊名：Leukemia Research
• 出版年：2012
• 期刊代码：186_01452126
• 类别：med
• 出版时间：August, 2012
• 卷：36
• 期：8
• 页码：e178-e181
• 文件大小：310 K

摘要

PAX5 rearrangements resulting in the expression of fusion transcripts account for 2-3%of childhood B-cell precursor acute lymphoblastic leukemia. Most PAX5 fusions are rare and many of them have only been described in a couple of, or even only in single, cases. We have identified the third case with a PAX5-AUTS2 fusion, which results from unbalanced t(7;9)(q11.2;p13.2) rearrangements. Our findings substantiate that PAX5-AUTS2 is a recurrent fusion gene in pediatric B-cell precursor acute lymphoblastic leukemia, and we summarize the clinical characteristics of such patients.