Interactions between vascular endothelial growth factor and neuroglobin

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• 作者：Kunlin Jin^a ; ^b ; Xiao Mao^a ; Lin Xie^a ; David A. Greenberg^a ; ^{dgreenberg@buckinstitute.org}
• 关键词：VEGF ; vascular endothelial growth factor ; Ngb ; neuroglobin ; HIF-1 ; hypoxia-inducible factor-1 ; SU1498 ; (E)-3-(3 ; 5-diisopropyl-4-hydroxyphenyl)-2-[(3-phenyl-n-propyl)amino-carbonyl]acrylonitrile ; VEGFR2 kinase inhibitor IV ; 3-(3-thienyl)-6-(4-methoxyphenyl
• 刊名：Neuroscience Letters
• 出版年：2012
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：21 June, 2012
• 卷：519
• 期：1
• 页码：47-50
• 文件大小：429 K

摘要

Vascular endothelial growth factor (VEGF) and neuroglobin (Ngb) participate in neuronal responses to hypoxia and ischemia, but the relationship between their effects, if any, is unknown. To address this issue, we measured Ngb levels in VEGF-treated mouse cerebrocortical cultures and VEGF levels in cerebrocortical cultures from Ngb-overexpressing transgenic mice. VEGF stimulated Ngb expression in a VEGFR2/Flk1 receptor-dependent manner, whereas Ngb overexpression suppressed expression of VEGF. These findings provide further insight into hypoxia-stimulated neuronal signaling pathways.