• 作者：S. Bertrand^a ; ^{sophie.bertrand@cjp.fr} ; M. Gauth&eacute ; ^a ; H. Mahammedi^b ; D. Culot^a ; C. Merlin^a ; A. Kelly^a ; A. Veyre^a ; J.-O. Bay^c ; L. Guy^d ; E. Miot-Noirault^e ; D. Mestas^a ; F. Cachin^a ; ^e
• 关键词：S&eacute ; minomes ; 18F-FDG TEP/TDM ; Bilan d&rsquo ; extension ; R&eacute ; ponse th&eacute ; rapeutique
• 刊名：M&eacute ; decine Nucl&eacute ; aire
• 出版年：2012
• 期刊代码：219_09281258
• 类别：med
• 出版时间：May, 2012
• 卷：36
• 期：5
• 页码：268-277
• 文件大小：390 K

Aims

To evaluate the value of PET/CT comparatively to CT in staging and restaging after chemotherapy of testicular seminoma, to assess quantitative methods and prognostic value of PET in post-chemotherapy residual masses.

Methods

Thirty-two patients and a maximum of 65 targeted lesions visualized on PET-CT and CT performed for staging and therapeutic response assessment were analysed and compared. Each lesion was quantified according to miscellaneous SUV normalized methods. Optimal threshold of SUV for prediction of residual disease was obtained (ROC method). The prognostic value of PET/CT at the completion of treatment was determined with progression free survival study (Kaplan-Meier method).

Results

PET/CT exhibited higher accuracy than CT in the initial staging and assessment of therapeutic response, respectively 98%versus 83.3%and 95.1%versus 75.6%. Quantification, whichever method, was not more efficient than visual reading for prediction of residual disease. Progression-free survival was higher with negative than with positive PET/CT (P = 0.0033).

Conclusion

Our work demonstrates that PET/CT exhibits better accuracy than CT in both staging and restaging at the end of treatment. Quantification methods do not improve accuracy of PET/CT for prediction of viable residual disease. The prognostic value of PET/CT appears very promising and needs to be confirmed by large prospective studies. PET/CT appears to be a relevant method of prognostic stratification of the risk of relapse in seminoma.