Motor and non-motor predictors of illness-related distress in Parkinson鈥檚 disease

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• 作者：Catharina Sjö ; dahl Hammarlund^a ; Peter Hagell^a ; ^b ; ^c ; ^{Peter.Hagell@hkr.se} ; Maria H. Nilsson^a
• 关键词：Distress ; Fatigue ; Motor symptoms ; Non-motor symptoms ; Parkinson&rsquo ; s disease ; Patient-reported impact
• 刊名：Parkinsonism and Related Disorders
• 出版年：2012
• 期刊代码：215_13538020
• 类别：med
• 出版时间：March, 2012
• 卷：18
• 期：3
• 页码：299-302
• 文件大小：121 K

摘要

Objective

To identify motor and non-motor symptoms independently associated with distress in Parkinson鈥檚 disease (PD).

Method

Clinical and patient-reported data from 118 people with PD (mean age and PD-duration, 64 and 8 years) were analyzed regarding associations with patient-reported distress using multiple regressions (controlling for age).

Results

Non-motor symptoms independently associated with distress were pain, fatigue, sleep, depression and anxiety (R², 0.81). The only significant motor aspect was mobility (R², 0.31). When considering both motor and non-motor symptoms, fatigue, pain, depression and sleep showed independent associations with distress (R², 0.76).

Conclusion

Distress in PD is primarily associated with non-motor features.