Anxiolytic-like effects of oleamide in group-housed and socially isolated mice
- 作者：Xiu Yan Wei ; Jing Yu Yang ; Ying Xu Dong ; Chun Fu Wu
- 关键词：Anxiety ; Elevated plus-maze test ; Hole-board test ; Light– ; dark test ; Oleamide ; Social isolation
- 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 出版年：2007
- 期刊代码：222_02785846
- 类别：med
- 出版时间：15 August 2007
- 卷：31
- 期：6
- 页码：1189-1195
- 文件大小：293 K
摘要
Oleamide (cis-9,10-octadecenoamide) is an endogenous sleep-inducing lipid and prototypic member of a new class of biological signaling molecules identified in recent years. In the present study, the anxiolytic-like effect of oleamide was studied in several experimental models of anxiety in group-housed and socially isolated mice. As the results show, socially isolated mice exhibited an anxiogenic-like profile in the elevated plus-maze test, the light/dark test, and the hole-board test, which could be significantly reversed by oleamide (10 or 20 mg/kg, i.p.). Moreover, oleamide significantly reduced the anxiety levels in grouped-housed mice. In the isolation-induced aggressive test, oleamide markedly reduced the attacking duration and increased the attacking latency. It is concluded that oleamide has an anxiolytic-like effect in socially isolated or group-housed mice, which suggests that fatty acid amides might be involved in the regulation of anxiety-related behavior in mice.