There is no data about the frequency of these allelic variants in Moroccan patients with Crohn's disease. The aim of our study is to genotype the NOD2 gene to assess the involvement of these three variants in susceptibility to Crohn's disease for Moroccans.
We carried out genotyping for the three variants p.Arg702Trp, p.Gly908Arg and p.Leu1007fsinsC of NOD2 gene using PCR-sequencing among 101 Moroccan patients with Crohn's disease and 107 healthy controls.
The three main variants of NOD2 gene were present in Moroccan patients with no significant difference compared to controls.
This preliminary study shows no evidence association of NOD2 gene with Crohn's disease in the Moroccan population.
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