Plasma soluble triggering receptor expressed on myeloid cells-1 in Crohn's disease

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• 作者：Vincent Billioud^a ; ^b ; Sé ; bastien Gibot^c ; ^d ; Fré ; dé ; ric Massin^e ; Abderrahim Oussalah^a ; ^b ; Jean-Baptiste Chevaux^a ; ^b ; Nicolas Williet^a ; ^b ; Jean-Pierre Bronowicki^a ; ^b ; Marc-André ; Bigard^a ; ^b ; Jean-Louis Gué ; ant^a ; ^b ; Laurent Peyrin-Biroulet^a ; ^b ; ^{peyrinbiroulet@gmail.com}
• 关键词：Crohn's disease ; Disease activity ; Triggering receptor expressed on myeloid cells-1
• 刊名：Digestive and Liver Disease
• 出版年：2012
• 期刊代码：79_15908658
• 类别：med
• 出版时间：June, 2012
• 卷：44
• 期：6
• 页码：466-470
• 文件大小：410 K

摘要

Background

No definite conclusions can be drawn from available data on the accuracy of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) to assess disease activity in Crohn's disease.

Aims

Plasma sTREM-1 levels were correlated with disease activity markers in Crohn's disease.

Methods

191 consecutive patients from a single referral centre (Nancy IBD cohort) were prospectively enrolled between June 1, 2005 and December 12, 2008. Plasma sTREM-1 levels were also assessed amongst 20 healthy controls.

Results

The sTREM-1 was detectable in 87 Crohn's disease patients (46%). Plasma sTREM-1 level was higher in Crohn's disease patients (interquartile range, 0-356) than in healthy controls (interquartile range, 0-15.1; P = 0.01). It was neither correlated with Crohn's disease activity index (r = 0.05, P = 0.56), C-reactive protein (r = 0.06, P = 0.53), nor with albumin (r = 鈭?.041, P = 0.66). Crohn's disease activity index, C-reactive protein and albumin median levels were similar between patients with positive sTREM-1 levels and those with undetectable sTREM-1 levels. Azathioprine (P = 0.06), infliximab (P = 0.68) and methotrexate (P = 0.56) did not influence sTREM-1 levels.

Conclusion

Plasma sTREM-1 does not appear to be an accurate marker of disease activity in Crohn's disease and cannot be recommended for assessing disease activity in these patients.