Characterization of metalloproteinases, oxidative status and inflammation levels in the different stages of fibrosis in HCV patients

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• 作者：F. Capone^a ; ¹ ; E. Guerriero^a ; ¹ ; A. Sorice^a ; P. Maio^b ; G. Colonna^c ; G. Castello^a ; S. Costantini^a ; ^{susan.costantini@unina2.it}
• 关键词：HCV ; Fibrosis ; Oxidative stress ; Cytokines ; MMPs ; Marker
• 刊名：Clinical Biochemistry
• 出版年：2012
• 期刊代码：55_00099120
• 类别：med
• 出版时间：May, 2012
• 卷：45
• 期：7-8
• 页码：525-529
• 文件大小：533 K

摘要

Objectives

This study was aimed at searching noninvasive markers of the transition from mild to severe fibrosis stage in HCV patients undergoing hepatic fibrosis.

Design and methods

Thirty-three patients affected by chronic HCV vs. twenty healthy donors were evaluated for the serum levels of several circulating matrix metalloproteinases (MMPs), TRAIL and 尾-NGF by multiplex biometric ELISA based immunoassay and anti- and pro-oxidant status (d-ROMs, BAP and NO) using a Diacron automated method.

Results

HCV patients displayed increased expression levels of MMP-8, MMP-9, TRAIL and 尾-NGF, and an imbalance between pro- and antioxidant status, that contribute to liver fibrosis.

Conclusions

Since the determination of these parameters represents a reliable and easily applicable method, these parameters are suggested as serum surrogate markers for HCV patients in the routine clinical practice.