Analysis of complex chromosomal rearrangements in adult patients with MDS and AML by multicolor FISH

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• 关键词：MDS ; AML ; Complex chromosomal aberrations ; mFISH ; mBAND
• 刊名：Leukemia Research
• 出版年：2007
• 期刊代码：186_01452126
• 类别：med
• 出版时间：January 2007
• 卷：31
• 期：1
• 页码：39-47
• 文件大小：386 K

摘要

We analyzed complex chromosomal aberrations in 37 adult patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) using classical cytogenetic method, FISH with locus-specific probes, multicolor FISH (mFISH) and multicolor banding (mBAND). Unbalanced structural aberrations, leading to a gain or loss of chromosomal material, were frequently observed in bone marrow cells. In 30 patients (81.1%) loss or rearrangement of chromosome 5, 7 and/or 11 was found. The most frequent numerical change was trisomy 8 as expected (detected in six patients—16.2%) and the most frequent breakpoints 5q13, 5q33, 7q31, 10p12, 11q23, 12p13, 17p11 and 21q22 were determined.