Regioselective palladium-catalyzed phenylation of ethyl 4-oxazolecarboxylate

详细信息	查看全文 | 推荐本文 |

• 作者：Christophe Hoarau ; Alexis Du Fou de Kerdaniel ; Nicolas Bracq ; Pierre Grandclaudon ; Axel Couture and Francis Marsais
• 关键词：Ethyl 4-oxazolecarboxylate ; Aryloxazoles ; Direct coupling ; Palladium
• 刊名：Tetrahedron Letters
• 出版年：2005
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：2005
• 卷：46
• 期：49
• 页码：8573-8577
• 文件大小：110 K

摘要

The efficient and regioselective palladium-catalyzed C-2 arylation of ethyl 4-oxazolecarboxylate 1 with phenyliodide is described. The different parameters (solvent, base, ligand and catalyst) for the optimal conditions of this arylation process have been screened.