TiO₂ nanotubes for bone regeneration

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• 作者：Karla S. Brammer ; Christine J. Frandsen ; Sungho Jin ^jin@ucsd.edu
• 关键词：nanostructure ; TiO2 nanotube ; osteoblast ; mesenchymal stem cell
• 刊名：Trends in Biotechnology
• 出版年：2012
• 期刊代码：146_01677799
• 类别：bio
• 出版时间：June, 2012
• 卷：30
• 期：6
• 页码：315-322
• 文件大小：1235 K

摘要

Nanostructured materials are believed to play a fundamental role in orthopedic research because bone itself has a structural hierarchy at the first level in the nanometer regime. Here, we report on titanium oxide (TiO₂) surface nanostructures utilized for orthopedic implant considerations. Specifically, the effects of TiO₂ nanotube surfaces for bone regeneration will be discussed. This unique 3D tube shaped nanostructure created by electrochemical anodization has profound effects on osteogenic cells and is stimulating new avenues for orthopedic material surface designs. There is a growing body of data elucidating the benefits of using TiO₂ nanotubes for enhanced orthopedic implant surfaces. The current trends discussed within foreshadow the great potential of TiO₂ nanotubes for clinical use.