Spatial organization of intracellular Ca²⁺ signals

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• 作者：Vera Konieczny¹ ; Michael V. Keebler¹ ; Colin W. Taylor ; ^{cwt1000@cam.ac.uk}
• 关键词：AC ; adenylyl cyclase ; AKAP ; A-kinase-anchoring protein ; [Ca2+]c ; cytosolic free Ca2+ concentration ; calmodulin ; CaM ; Cav ; voltage-gated Ca2+ channel ; CICR ; Ca2+-induced Ca2+ release ; ER ; endoplasmic reticulum ; IP3 ; inositol 1 ; 4 ; 5-trisphosphate ; IP3R ; IP3
• 刊名：Seminars in Cell and Developmental Biology
• 出版年：2012
• 期刊代码：186_10849521
• 类别：bio
• 出版时间：April, 2012
• 卷：23
• 期：2
• 页码：172-180
• 文件大小：628 K

摘要

The ability of Ca²⁺, the simplest of all intracellular messengers, selectively to regulate so many cellular behaviours is due largely to the complex spatiotemporal organization of intracellular Ca²⁺ signals. Most signalling pathways, including those that culminate in Ca²⁺ signals, comprise sequences of protein-protein interactions linked by diffusible messengers. Using specific examples to illustrate key principles, we consider the roles of both components in defining the spatial organization of Ca²⁺ signals. We discuss evidence that regulation of most Ca²⁺ channels by Ca²⁺ contributes to controlling the duration of Ca²⁺ signals, to signal integration and, via Ca²⁺-induced Ca²⁺ release, to defining the spatial spread of Ca²⁺ signals. We distinguish two types of protein-protein interaction: scaffolds that allow rapid local transfer of diffusible messengers between signalling proteins, and interactions that directly transfer information between signalling proteins. Store-operated Ca²⁺ entry provides a ubiquitous example of the latter, and it serves also to illustrate how Ca²⁺ signals can be organized at different levels of spatial organization - from interactions between proteins to interactions between organelles.