Mechanisms of FGFR-mediated carcinogenesis

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• 作者：Imran Ahmad^a ; ^b ; Tomoko Iwata^b ; Hing Y. Leung^a ; ^b ; ^{h.leung@beatson.gla.ac.uk}
• 关键词：FGF ; FGFR ; Receptor tyrosine kinase ; Signalling ; Cancer ; Cancer therapy
• 刊名：Biochimica et Biophysica Acta (BBA)/Molecular Cell Research
• 出版年：2012
• 期刊代码：20_01674889
• 类别：bio
• 出版时间：April, 2012
• 卷：1823
• 期：4
• 页码：850-860
• 文件大小：488 K

摘要

In this review, the evidence for a role of fibroblast growth factor receptor (FGFR) mediated signalling in carcinogenesis are considered and relevant underlying mechanisms highlighted. FGF signalling mediated by FGFR follows a classic receptor tyrosine kinase signalling pathway and its deregulation at various points of its cascade could result in malignancy. Here we review the accumulating reports that revealed the association of FGF/FGFRs to various types of cancer at a genetic level, along with in vitro and in vivo evidences available so far, which indicates the functional involvement of FGF signalling in tumour formation and progression. An increasing number of drugs against the FGF pathways is currently in clinical testing. We will discuss the strategies for future FGF research in cancer and translational approaches.