Association of interferon-gamma gene polymorphisms with susceptibility to oral lichen planus in the Thai population

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• 作者：Ingorn Kimkong^a ; ^b ; Jeerawat Nakkuntod^c ; Pimpayao Sodsai^c ; Nattiya Hirankarn^d ; Nakarin Kitkumthorn^e ; ^{nakarinkit@hotmail.com}
• 关键词：Interferon-纬 ; Oral lichen planus ; Polymorphism
• 刊名：Archives of Oral Biology
• 出版年：2012
• 期刊代码：25_00039969
• 类别：med
• 出版时间：May, 2012
• 卷：57
• 期：5
• 页码：491-494
• 文件大小：247 K

摘要

Objective

Interferon-gamma (IFN-纬) is highly expressed in oral lichen planus (OLP). The IFN-纬 (+874 in intron 1, rs2430561) TT genotype, which has been reported to be associated with high IFN-纬 production, was hypothesized to be associated with susceptibility to OLP in the Thai population.

Design

Genomic DNA samples from 74 OLP and 268 healthy controls were evaluated for IFN-纬 polymorphisms by polymerase chain reaction with sequence-specific primers (PCR-SSP) and direct sequencing method.

Results

The T allele was significantly associated with an increased risk of OLP development as compared to the A allele (OR = 1.76, P = 0.004; P_c = 0.02). The effect of the T allele was similar to an autosomal recessive disorder; the presence of TT genotype (when compared to AA and AT) conferred an OR of 2.61, P = 0.008; P_c = 0.04.

Conclusions

We found an association between IFN-纬 +874A/T polymorphism and susceptibility to OLP. However, an association study utilising a larger sample size and patients from other races apart from the Asian population should be performed to further verify these findings.