Open, parallel-group studies were performed in NVAF patients treated with VKA, which was stopped aiming for an international normalized ratio (INR) of 鈮?#xA0;2 before randomization. Study I: 38 patients randomized to AZD0837 (150, 250 or 350 mg) or ximelagatran 36 mg twice daily for 10-14 days. Study II: 27 patients randomized to AZD0837 250 mg twice daily or VKA titrated to an INR of 2-3 for 10-14 days. A control group of 20 healthy elderly subjects without NVAF or anticoagulant treatment was also studied. Size of thrombus formed on pig aorta strips was measured after a 5-minute perfusion at low shear rate with blood from the patient/control subject.
Thrombus formation was inhibited by AZD0837 and ximelagatran. Relative to untreated patients, a 50%reduction of thrombus size was estimated at plasma concentrations of 0.6 and 0.2 渭mol/L for AR-H067637 and melagatran, respectively. For patients receiving VKA treatment, the thrombus size was about 15%lower compared with healthy elderly controls.
Effects of AZD0837 and ximelagatran on thrombus formation were similar or greater than for VKA therapy and correlated with plasma concentrations of their active forms.
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