Interleukin (IL)-6, tumour necrosis factor alpha (TNF-伪) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression

详细信息	查看全文 | 推荐本文 |

• 作者：Yang Liu^a ; Roger Chun-Man Ho^a ; ^{roger_ho@nuhs.edu.sg} ; Anselm Mak^b ; ¹
• 关键词：Cytokine ; Depression ; Inflammation ; Meta-analysis ; Meta-regression
• 刊名：Journal of Affective Disorders
• 出版年：2012
• 期刊代码：141_01650327
• 类别：med
• 出版时间：August, 2012
• 卷：139
• 期：3
• 页码：230-239
• 文件大小：899 K

摘要

Background

Many studies have explored the association between soluble interleukin-2 receptor (sIL-2R), cytokines and major depressive disorder (MDD). However, the results of these studies were not consistent. The aim of our study is to compare the levels of sIL-2R and cytokines in the blood between MDD patients and controls by a meta-analysis and to identify moderators accounting for potential heterogeneity in the levels of sIL-2R and cytokines in MDD patients versus controls by meta-regression analyses.

Methods

A comprehensive literature search was performed to identify studies comparing the levels of sIL-2R and cytokines between MDD patients and controls. We pooled the effect sizes for standardized mean differences (SMD) of the levels of sIL-2R and cytokines. We also performed meta-regression and sensitivity analyses to investigate the roles of age, gender, sample type, ethnic origin and selected studies' quality in explaining potential heterogeneity and differences in results respectively.

Results

Twenty-nine studies were selected for this analysis. The levels of sIL-2R, TNF-伪 and IL-6 in MDD patients were significantly higher than those of healthy controls (SMD = 0.555, p < 0.001, SMD = 0.567, p = 0.010; SMD = 0.680, p < 0.001). Mean age of all subjects was a significant moderator to explain the high heterogeneity of IL-6. Sensitivity analysis found that European but not non-European subjects have higher levels difference of sIL-2R, TNF-伪 and IL-1尾 between MDD patients and controls.

Limitation

The severity of MDD was not considered.

Conclusion

The blood levels of sIL-2R, TNF-伪 and IL-6 were significantly higher in MDD patients than controls. Age, samples source and ethnic origins may play a potential role in heterogeneity.