γ-Glutamyltransferase, redox regulation and cancer drug resistance
- 作者：Alfonso Pompella ; Aless ; ro Corti ; Aldo Paolicchi ; Chiara Giommarelli ; Franco Zunino
- 关键词：Arachnids ; Insect toxins ; Scorpion venoms ; Ionic channels ; Sodium channel ; Spider venoms
- 刊名：Current Opinion in Pharmacology
- 出版年：2007
- 期刊代码：11_14714892
- 类别：pha
- 出版时间：August 2007
- 卷：7
- 期：4
- 页码：360-366
- 文件大小：504 K
摘要
Arachnids have a venom apparatus and secrete a complex chemical mixture of low molecular mass organic molecules, enzymes and polypeptide neurotoxins designed to paralyze or kill their prey. Most of these toxins are specific for membrane voltage-gated sodium channels, although some may also target calcium or potassium channels and other membrane receptors. Scorpions and spiders have provided the greatest number of the neurotoxins studied so far, for which, a good number of primary and 3D structures have been obtained. Structural features, comprising a folding that determines a similar spatial distribution of charged and hydrophobic side chains of specific amino acids, are strikingly common among the toxins from spider and scorpion venoms. Such similarities are, in turn, the key feature to target and bind these proteins to ionic channels. The search for new insecticidal compounds, as well as the study of their modes of action, constitutes a current approach to rationally design novel insecticides. This goal tends to be more relevant if the resistance to the conventional chemical products is considered. A promising alternative seems to be the biotechnological approach using toxin-expressing recombinant baculovirus. Spider and scorpion toxins having insecticidal activity are reviewed here considering their structures, toxicities and action mechanisms in sodium channels of excitable membranes.