Depression of mitochondrial metabolism by downregulation of cytoplasmic deacetylase, HDAC6

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• 作者：Kazuo Kamemura^a ; ^{k_kamemura@nagahama-i-bio.ac.jp} ; Mitsutaka Ogawa^a ; Saki Ohkubo^a ; Yasuhiro Ohtsuka^a ; Yu Shitara^a ; Tohru Komiya^a ; Satoko Maeda^b ; Akihiro Ito^b ; ^c ; Minoru Yoshida^b ; ^c ; ^d
• 关键词：HDAC6 ; histone deacetylase 6 ; MEF ; mouse embryonic fibroblast ; CS ; citrate synthase
• 刊名：FEBS Letters
• 出版年：2012
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：7 May, 2012
• 卷：586
• 期：9
• 页码：1379-1383
• 文件大小：408 K

摘要

Mitochondria perform multiple functions critical to the maintenance of cellular homeostasis. Here we report that the downregulation of histone deacetylase 6 (HDAC6) causes a reduction in the net activity of mitochondrial enzymes, including respiratory complex II and citrate synthase. HDAC6 deacetylase and ubiquitin-binding activities were both required for recovery of reduced mitochondrial metabolic activity due to the loss of HDAC6. Hsp90, a substrate of HDAC6, localizes to mitochondria and partly mediates the regulation of mitochondrial metabolic activity by HDAC6. Our finding suggests that HDAC6 regulates mitochondrial metabolism and might serve as a cellular homeostasis surveillance factor.