EN-RAGE (extracellular newly identified receptor for advanced glycation end-products binding protein) and mortality of long-term hemodialysis patients: Aprospective observational cohort study

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• 作者：Marta Kalousov&aacute ; ^a ; ^{marta.kalousova@lf1.cuni.cz} ; ^{marta.kalousova@vfn.cz} ; ^{marta.kalousova@seznam.cz} ; Ale&scaron ; A. Kub臎na^a ; Hana Ben&aacute ; kov&aacute ; ^a ; Sylvie Dusilov&aacute ; -Sulkov&aacute ; ^b ; Vladimí ; r Tesa艡^c ; Tom&aacute ; &scaron ; Zima^a
• 关键词：Biomarker ; Cardiovascular ; EN-RAGE ; Hemodialysis ; Infection ; Inflammation ; Mortality ; Risk ; S100A12
• 刊名：Clinical Biochemistry
• 出版年：2012
• 期刊代码：55_00099120
• 类别：med
• 出版时间：May, 2012
• 卷：45
• 期：7-8
• 页码：556-560
• 文件大小：253 K

摘要

Objectives

EN-RAGE is extracellular newly identified receptor for advanced glycation end-products binding protein playing a role in inflammation. The aim was to test the relationship of EN-RAGE to prognosis of long-term hemodialysis patients (HD).

Design and methods

This is a prospective observational cohort study in 261 HD patients followed up for five years. Laboratory parameters were measured at the beginning of the study.

Results

EN-RAGE was slightly but unsignificantly increased in HD patients compared with healthy controls and correlated significantly with inflammatory markers. Univariate Cox analysis demonstrated EN-RAGE as a significant predictor for mortality due to infection (HR (95%CI): 1.305 (1.063-1.602), per standard deviation, p = 0.01), but this significance disappeared in multivariate Cox analysis when CRP was included into the model.

Conclusions

Our study demonstrates EN-RAGE as an inflammatory biomarker. It is related to mortality of HD patients due to infection, but in our study, it did not provide additional information to CRP.