- 作者：Laura Regueras<sup>asup> ; Pablo Prieto<sup>asup> ; Marí ; a Teresa Muñ ; oz-Calvo<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>csup> ; Jesú ; s Pozo<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>csup> ; Lissette Arguinzoniz<sup>asup> ; Jesú ; s Argente<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>csup><sup> ; sup><sup>jesus.argente@uam.essup>
- 关键词：Sí ; ndrome de Down ; Hipotiroidismo ; Hipertiroidismo ; Diabetes mellitus
- 刊名：Medicina Cl铆nica
- 出版年：2011
- 期刊代码：pca254_00257753
- 类别：med
- 出版时间：9 April 2011
- 卷：136
- 期：9
- 页码：376-381
- 文件大小：233 K
ss="h4">Background and objective
Children and adolescents with Down syndrome (DS) show a greater prevalence of endocrinological abnormalities when compared with the general population. Our aim is to analyze endocrinological abnormalities in 1,105 patients with DS.
ss="h4">Patients and methods
A review of 1,105 cases of children and adolescents with DS under care in our Department (ages between 0 and 18 years) analyzed retrospectively the presence of thyroid pathology and diabetes mellitus throughout development.
ss="h4">Results
Our data indicate the presence of endocrinological abnormalities in 222 patients [216 with thyroid pathology (19.5%) and 6 cases with diabetes mellitus type 1 (0.45%)]. Subclinical primary hypothyroidism was present in 168 cases, congenital primary hypothyroidism in 15 cases, clinical primary hypothyroidism in 24 cases and 5 cases had hyperthyroidism. In addition, 16.9%of these patients exhibit criteria of obesity and 28.2%had overweight. The prevalence of endocrinological comorbidities in children and adolescents with DS is higher than in the general population.
ss="h4">Conclusion
Subclinical primary hypothyroidism, due to autoimmune causes in most of the patients, without a higher incidence in females, is the most common endocrinological pathology associated with DS. The high frequency of thyroid pathology and diabetes mellitus type 1 in these patients should induce us to have a closer clinical control of children and adolescents with DS.