The oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi
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- 作者：Xiaofei Shang (42) (43)
Dongsheng Wang (42) (43)
Xiaolou Miao (42) (43)
Xuezhi Wang (42) (43)
Jianxi Li (42) (43)
Zhiqiang Yang (42) (43)
Hu Pan (42) (43) - 关键词：Rabbits ; Psoroptes cuniculi ; Oxidative status ; Superoxide dismutase ; Inflammatory factor
- 刊名：Parasites & Vectors
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：7
- 期：1
- 全文大小：207 KB
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Dongsheng Wang (42) (43)
Xiaolou Miao (42) (43)
Xuezhi Wang (42) (43)
Jianxi Li (42) (43)
Zhiqiang Yang (42) (43)
Hu Pan (42) (43)
42. Key Lab of New Animal Drug Project, Lanzhou, 730050, Gansu Province, People’s Republic of China
43. Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Science, Lanzhou, 730050, People’s Republic of China - ISSN：1756-3305
文摘
Background Psoroptes cuniculi can parasitise the ear canal of the rabbit, and cause the afflicted animals to cease feeding and become severely debilitated, sometimes resulting in death. In this study, we examined the oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi and investigated the pathogenesis of this disease. Methods A total of 24 rabbits were divided into a healthy rabbit group and two infested rabbit groups. After weighing the rabbits, approximately 5?ml of blood was obtained from each animal. Then, the blood serum was extracted and used to assess the levels of antioxidant enzymes and inflammatory factors. Results Compared to the healthy rabbits, the activities of catalase and glutathione-S-transferase and the level of malonyldialdehyde were increased, but the activity of superoxide dismutase was reduced in the infested rabbits. At the same time, a variety of inflammatory cells were activated, and the levels of inflammatory factors such as prostaglandin E2, interleukin-6, interleukin-8 and transforming growth factor-β1 were increased in peripheral blood. Conclusion Animal acariasis was associated with immunosuppressive disorders and inflammatory reaction. These results advance our understanding of the pathogenesis of Psoroptes cuniculi infestation in rabbits and can help guide the effectual treatment of this disease in clinics.